Active TGF-1 induces many pathways but we highlight here Rho-dependent processes that include increases (light gray arrows left) in actin polymerization, dissociation of MRTF-A from G-actin, and translocation of MRTF-A to the nucleus where with SRF induces cytoskeletal genes, some focal adhesion proteins, including Hic-5 (black arrow, demonstrated that when carbon tetrachloride is removed and fibrosis subsides, 50% of the myofibroblasts do not undergo apoptosis
Active TGF-1 induces many pathways but we highlight here Rho-dependent processes that include increases (light gray arrows left) in actin polymerization, dissociation of MRTF-A from G-actin, and translocation of MRTF-A to the nucleus where with SRF induces cytoskeletal genes, some focal adhesion proteins, including Hic-5 (black arrow, demonstrated that when…