By therefore doing, hopefully the relevant chemical substance space at different sirtuin dynamic sites could possibly be even more comprehensively explored, and more powerful and selective cyclic peptide-based SIRT5 inhibitors harboring the SIRT5 inhibitory warhead N-carboxyethyl-thiocarbamoyl-lysine could possibly be found also

By therefore doing, hopefully the relevant chemical substance space at different sirtuin dynamic sites could possibly be even more comprehensively explored, and more powerful and selective cyclic peptide-based SIRT5 inhibitors harboring the SIRT5 inhibitory warhead N-carboxyethyl-thiocarbamoyl-lysine could possibly be found also. ? Open in another window Scheme 1 The solid…