dASOs 6w2 and 6w5 simultaneously target BIRC6 and an additional secondary IAP target (cIAP1 or survivin)

dASOs 6w2 and 6w5 simultaneously target BIRC6 and an additional secondary IAP target (cIAP1 or survivin). oligonucleotides that simultaneously target BIRC6 and another co-upregulated IAP member (dASOs). Two dASOs, targeting BIRC6+cIAP1 and BIRC6+survivin, showed considerable inhibition of CRPC cell proliferation, exceeding that acquired with solitary BIRC6 focusing on. The growth…