2009;137:472C84

2009;137:472C84. chaperone DAXX prevents CENP-A mislocalization and rescues the reduced interkinetochore distance and CIN phenotype in CENP-A overexpressing cells. In summary, our results establish that CENP-A overexpression and mislocalization result in a CIN phenotype in human cells. This study provides insights into how overexpression of CENP-A may contribute to CIN…

dASOs 6w2 and 6w5 simultaneously target BIRC6 and an additional secondary IAP target (cIAP1 or survivin)

dASOs 6w2 and 6w5 simultaneously target BIRC6 and an additional secondary IAP target (cIAP1 or survivin). oligonucleotides that simultaneously target BIRC6 and another co-upregulated IAP member (dASOs). Two dASOs, targeting BIRC6+cIAP1 and BIRC6+survivin, showed considerable inhibition of CRPC cell proliferation, exceeding that acquired with solitary BIRC6 focusing on. The growth…