How the mitochondrial fusion/fission machinery is regulated, what causes changes in mitochondrial localization, what senses and instructs lineage-specific differential mitochondrial mass accumulation and maintenance, and what factors facilitate transitions in metabolism and cell fates remains a significant area of ongoing and future investigations

How the mitochondrial fusion/fission machinery is regulated, what causes changes in mitochondrial localization, what senses and instructs lineage-specific differential mitochondrial mass accumulation and maintenance, and what factors facilitate transitions in metabolism and cell fates remains a significant area of ongoing and future investigations. PSC metabolism regulates the activities of epigenetic…

Supplementary MaterialsS1 Text: Detailed description of models and fitting procedures

Supplementary MaterialsS1 Text: Detailed description of models and fitting procedures. poorly understood. Conceptually, homeostatic mechanisms must fall into the broad categories of neutral (simple random birthCdeath models), competition (regulation of cell figures through quorum-sensing, perhaps via limiting shared resources), adaptation (including cell-intrinsic changes in homeostatic fitness, defined as net growth…