Supplementary MaterialsSupplementary Information 41467_2019_12255_MOESM1_ESM

Supplementary MaterialsSupplementary Information 41467_2019_12255_MOESM1_ESM. unclear systems of cell loss of life. Right here we investigate replication stress-driven mitotic catastrophe in individual cells and see that INCB3344 replication tension principally induces mitotic loss of life signalled through two indie pathways. In p53-affected cells we discover that lethal replication tension confers WAPL-dependent…