Oncogene

Oncogene. compounds, we identified Mc as novel SENP1 inhibitor that inhibited proliferation of prostate cancer cells and deSUMOylation assay (Figure ?(Figure1B).1B). The IC50 of AMD 3465 Hexahydrobromide Mc-induced SENP1C inhibition was 15.37 M (Figure ?(Figure1C).1C). As only SENP1C contained the appropriate catalytic domain, we next examined whether Mc inhibited the…