Seven designs were subsequently selected for experimental characterization based on (i) hydrophobic packing of the naphthyl group, (ii) supporting interactions for the Asp/Glu residue (salt bridges or interactions to stabilize the unfavorable charge with good packing of the side chain), and (iii) packing of the lysine side chain to restrict its movement
Seven designs were subsequently selected for experimental characterization based on (i) hydrophobic packing of the naphthyl group, (ii) supporting interactions for the Asp/Glu residue (salt bridges or interactions to stabilize the unfavorable charge with good packing of the side chain), and (iii) packing of the lysine side chain to restrict…